Ущемление грыжи пищеводного отверстия - сложная проблема неотложной хирургии: обзор литературы и клинический опыт авторов

Резюме

Введение. Заворот желудка является наиболее редким типом грыжи пищеводного отверстия диафрагмы (ГПОД) (<5%), характеризующимся смещением желудка или большей его части в заднее средостение. Это очень редкое состояние сопровождается высоким риском ущемления грыжи и развития кишечной непроходимости - жизнеугрожающих осложнений, требующих оказания неотложной помощи.

Материал и методы. Клинический случай 1: 62-летняя пациентка с ущемлением параэзофагеальной грыжи, осложненной ишемией тканей и перфорацией желудка. Выполнена тотальная гастрэктомия с эзофагоеюностомией по Roux en-Y. Пациентка выписана из лечебного учреждения через 15 дней. Каких-либо осложнений не зарегистрировано. Клинический случай 2: 84-летняя пациентка, у которой по данным компьютерной томографии желудок, часть тощей кишки и поджелудочной железы оказались втянуты в грыжевой мешок, образовавшийся в грудной клетке. Пациентке была проведена диагностическая лапаротомия, выявившая отек пилорического и антрального отделов желудка, а затем - тотальная гастрэктомия с эзофагоеюностомией по Roux en-Y. Пациентка была переведена в отделение интенсивной терапии, ее состояние не удалось стабилизировать, у нее развился сепсис. Она умерла на 7-й день после операции. Клинический случай 3: 76-летний пациент с ущемлением параэзофагеальной грыжи, осложненной ишемией тканей, поступил в отделение для получения неотложной помощи. Диагностическая лапаратомия выявила ущемление ГПОД. Была выполнена резекция кардии и тела желудка. Пациент был переведен в отделение интенсивной терапии, но его состояние не удалось стабилизировать, он умер вследствие развившегося сепсиса.

Обсуждение. Ущемление параэзофагеальной грыжи или заворот желудка требует неотложного хирургического вмешательства, поскольку ущемление может стать необратимым, кроме того, высок риск развития массивного кровотечения в результате растяжения и дилатации сосудов, ишемии и перфорации желудка. Тем не менее четкие данные или рекомендации по лечению острой параэзофагеальной грыжи или заворота желудка отсутствуют. В рамках предпринятого обзора литературы авторы проанализировали отчеты о клинических случаях и сериях случаев ущемления ГПОД по публикациям в базе данных Pubmed за период с 2013 по 2019 г. 

Заключение. Ведение пациентов с ущемлением грыжи пищевода остается трудной хирургической задачей. Лечение нестабильных пациентов требует применения открытой хирургии, у стабильных пациентов целесообразно неотложное проведение лапароскопической редукции и восстановления.

Ключевые слова:ущемление грыжи пищеводного отверстия диафрагмы, кишечная непроходимость, параэзофагеальная грыжа, заворот желудка

Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.
Для цитирования: Павоне Д., Тарталья Н., Ди Лашиа А., Вовола Ф., Маддалена Ф., Ферзини А., Пачилли М., Амбрози А. Ущемление грыжи пищеводного отверстия - сложная проблема неотложной хирургии: обзор литературы и клинический опыт авторов // Клин. и эксперимент. хир. Журн. им. акад. Б.В. Петровского. 2020. Т. 8, No 2. С. 51-57. DOI: 10.33029/2308-1198-2020-8-2-51-57
Статья поступила в редакцию 20.12.2019. Принята в печать 26.03.2020.

Hiatal hernias occur when intra-abdominal contents herniate through the esophageal hiatus into the mediastinum. There are four types: type I occurs when the stomach slides into the mediastinum thus displacing the gastroesophageal junction into the thorax (sliding hiatal hernia), type II and III paraesophageal hernias result from herniation of the stomach through the esophageal hiatus and subsequent organoaxial and mesoenteroaxial rotation respectively, and type IV hernias involve organs other than the stomach herniating through the hiatus into the thorax [1].

Upside-down stomach (UDS) is the rarest type of hiatal hernia (<5%). It is characterized by herniation of the entire stomach or most gastric portions into the posterior mediastinum [2-4]. Both gastroesophageal junction and parts of the stomach migrate intra thoracically, thus UDS represents a large mixed type - sliding and paraesophageal (type 3) hernia [5]. By many authors, UDS is also referred to as type 4 hiatal hernia.

The pathophysiology of hiatal hernias remains poorly understood. Three pathogenic components are widely found in the literature which can individually exist in different proportions increased intra-abdominal pressure (trans diaphragmatic pressure gradient); esophageal shortening (fibrosis, vagal nerve stimulation); widening of the diaphragmatic hiatus due to congenital or acquired structural changes of periesophageal ligaments and muscular crura of the hiatus [6-8]. The latter include abnormalities of elastin, collagens, and matrix metalloproteinases [9-11]. As hiatal and true paraesophageal hernia, UDS can manifest itself clinically in a wide variety of symptoms including substernal pain, heartburn, postprandial distress and fullness, dysphagia, postprandial nausea and vomiting.

UDS itself is a very rare condition it is associated with a risk of incarceration as well as volvulus development. These complications can cause acute gastric outlet obstruction and thereby present clinically as acute abdomen. Further complications are acute and severe gastric bleeding, ischemia and perforation. All of these complications represent true emergencies as life-threatening conditions. Prevalence of acute symptoms or incarceration in paraesophageal hernia was reported to be 30,4% [12-14]. The aim of this article is to present these three cases step by step in order to identify the pitfalls and bonus points on the path to a correct diagnosis and treatment.

Material and methods

Case 1. A 62-year-old woman with a medical history of arterial hypertension, dyslipemia, and an asymptomatic hiatal hernia is admitted to our hospital owing to thoracic and abdominal pain. A few hours after admission, the patient presents an overall worsening, with hypotension, tachycardia and profuse sweating. The CT scan shows a hiatal hernia with a mesenteroaxial stomach volvulus inside. Gas and abundant periesophageal liquid are also observed. These findings are compatible with the diagnosis of an incarcerated and ischemic paraesophageal hiatal hernia with a stomach perforation (fig. 1). CT scan also shows moderate amount of perihepatic, perisplenic liquid. Suspecting an incarcerated hiatal hernia with stomach perforation, the patient is taken to the operating room for a laparotomy during the early hours. An exploratory laparotomy was performed which showed edematous intraperitoneal portion of the pyloric antrum, but the proximal stomach was herniating to the thorax. On attempts to reduce hernia, toxic fluid was drained out. The fundus and proximal body of the stomach was found to be strangulated and gangrenous. A total gastrectomy was performed with a Roux en-Y esophago-jejunostomy. Patient recovered over time with supportive care. Oral feeds were started 10 days after verifying anastomotic integrity with contrast study. The patient was discharged after 15 days without any complication.

Case 2. A 84-year-old woman with a medical history of a hiatal hernia. She complained of shortness of breath, chest pain, severe anorexia, and weight loss of 5 kg over the 3 previous months. She was referred to our clinic for further investigation and treatment. A chest X-ray revealed that her heart was retracted on the right side, and the hernia contents had physically compressed her left lung on the cranial side. Trans thoracic echocardiography could not reveal the accurate ejection fraction due to the unusual location of her heart. She was therefore diagnosed with severe combined ventilator impairment. Moreover, an enhanced CT examination revealed that all of her stomach and parts of her jejunum and pancreas were drawn into the hernia sac (fig. 2). An exploratory laparotomy was performed which showed edematous intraperitoneal portion of the pyloric antrum, the fundus and proximal body of the stomach was found to be strangulated and gangrenous. First, the hernia was reduced after the herniated jejunum was pulled out from the mediastinum and a total gastrectomy was performed with a Roux en-Y esophago-jejunostomy. The patient was placed in the intensive care unit, where she was instable and she developed sepsis. She died on 7th postoperative day.

Case 3. A 76-year-old man with a history of type 2 diabetes mellitus, hypertension and asyntomatic hiatal hernia presented in our department as emergency with a 4-dayhistory of severe retrosternal and left chest discomfort and worsening pain. He had been unable to swallow anything for the previous 12 h but had intermittent dysphagia for 4 weeks and was unable to swallow solids for 2 weeks. Although nauseated, he could not vomit. Twenty-four hours after admission, CT scan showed an intrathoracic and infradiaphragmatic stomach, with gas and abundant periesophageal, perihepatic and perisplenic liquid, observed. These findings are compatible with the diagnosis of an incarcerated and ischemic paraesophageal hiatal hernia (fig. 3). An exploratory laparotomy was performed which showed the fundus and proximal body of the stomach strangulated and gangrenous. A section of the cardias and the body of the stomach was performed. The patient was placed in the intensive care unit, where he was instable and he developed sepsis which caused his death.

Discussion

most patients with paraesophageal hernia (PEH) are asymptomatic, and many of them have non-specific complaints, such as epigastric or chest pain and vomiting, arising from obstruction. Other findings such GERD, iron-deficiency and anaemia maybe also present [15-16].

Upside-down stomach (UDS) usually presents with Borchadt’s triad: unproductive retching, epigastric pain and distention, and the inability to pass a nasogastric tube.

Surgery for incarcerated paraesophageal hernia or UDS has to be performed emergently as incarceration can become irreversible and severe bleeding can occur due to distension and vascular dilation. Moreover, ischemia and gastric perforation are on the verge. However, there are no clear evidence or existing guidelines on the management of acute paraesophageal hernia PEH or UDS [17].

Clinical case reports and case series studies of strangulated hiatal hernia published between 2013 and 2019 were identified in PubMed (Medline database) using the search terms: strangulated hiatal hernia, gastric incarceration, paraesophageal hernia, Upside-down stomach. Identified publications were screened for inclusion using the following criteria: patient information, clinical history, laboratory data, and diagnostic methods were clearly described. A total of 11 publications, with a total of 12 cases, were selected for analysis (table) [17-27].

Schiergens T.S. et al. (2013) [17] analyzed the case of a 32-year-old male presented with acute intolerant epigastralgia and anterior chest pain associated with acute onset of nausea and vomiting. Chest radiography and computer tomography showed an incarcerated UDS. After immediate esophago-gastroscopy, urgent laparoscopic reduction, repair with a 360° floppy Nissen fundoplication was performed. Postoperatively the patient recovered very well and was discharged five days later without any complication.

Ponte A. et al. (2014) [18] presented the case of an 89-year-old man with valvular heart disease and third-degree atrioventricular block with a permanent pacemaker presented with a 1-day history of nausea, coffee ground emesis, and dyspnea. A chest radiograph showed a giant hiatal hernia with migration of the entire stomach with an air-fluid level inside. The patient was referred to surgery which revealed total gastric herniation with incarceration and signs of ischemia that reversed spontaneously after reduction of the hernia sac. A laparoscopic hernia repair was performed followed by a fundoplication. Patient was discharged without any complication.

Martinez-Perez A. et al. (2014) [19] showed the case of a 77-year-old woman with abdominal pain of 48-h progression that initially was epigastric and then became generalized. A plain chest x-ray showed a large hiatal hernia with probable stomach protrusion and an image of paragastric gas (suggesting pneumoperitoneum); an abdominal computed tomography scan revealed paraesophageal gastric herniation with organoaxial volvulus; it also showed signs of ischemia in the gastric wall. The patient underwent laparotomy through a midline incision and atypical tubular gastrectomy was performed. The patient was placed in the intensive care unit. Her previous respiratory and renal failure worsened, progressing to multiorgan failure and consequent death.

Di Saverio S. et al. (2014) [20] presented the case of a 67-year-old woman presented to the emergency department with severe dysphagia, persistent vomiting, epigastric pain and abdominal distension. Radiographic findings were consistent with incarcerated paraesophageal hiatus hernia with gastric distension. Computed tomography with water-soluble contrast showed the “upsidedown” stomach radiologic sign confirming the diagnosis. An incarcerated gastric hernia was reduced into the abdomen during emergency laparoscopy. Given the large size of the hiatal defect, laparoscopic repair was performed with u-shaped prosthetic mesh placement and intracorporeal stitches. The patient’s postoperative course was uneventful, and she was discharged six days later.

Iqbal A. et al. (2014) [21] presented the case of a middle-aged male with no previous history of esophageal hernia who presented with acute chest and abdominal pain. The patient was diagnosed to have a type 2 paraesophageal hernia with gastro-thorax. Laparotomy was performed during which it was found that herniated segment of the stomach had strangulated and gangrenous. Thoracotomy was performed and gangrenous stomach segment resected. A roux- en-Y esophagojejunostomy was performed. Diaphragmatic defect was plicated. Patient recovered with adequate post operative support and was discharged without any complication.

Díez Ares J.Á. et al. (2016) [22] showed the case of a 67-year-old woman with a medical history of hiatal hernia was admitted to the hospital with thoracic and abdominal pain. The CT scan shows a hiatal hernia with a mesentero-axial stomach volvulus inside. These findings are compatible with the diagnosis of an incarcerated and ischemic paraesophagic hiatal hernia with a stomach perforation. An atypical gastrectomy of the greater curvature with a gastropexy is performed along with fixation to the anterior abdominal wall. Surgery is completed with a feeding jejunostomy. During the postoperative period, the patient has a mediastinal collection, which is treated conservatively with antibiotics. The patient is dis- charged after 12 days.

Gryglewski A. et al. (2016) [23] presented the case of a 54 year-old female was admitted to the emergency department presenting signs of acute epigastric pain radiating into thorax. Computed tomography revealed a giant hiatal hernia with incarceration of the gastric trunk. Immediate operation for reduction of the incarcerated stomach and repair of the hiatal defect was performed. The patient was discharged without any complication and was followed up at the surgical outpatient department.

Kiyani A. et al. (2017) [24] presented the case of a 56-year-old female with lung cancer status post left lower lobectomy undergoing chemotherapy with intermittent nausea and upper abdominal pain for a few weeks. Barium study and computed tomography revealed acute mesenteroaxial gastric volvulus and she was treated with emergent exploratory laparotomy for volvulus reduction, diaphragmatic defect repair and left tube thoracostomy. She tolerated the procedure well and experienced no complications. A control CT showed that the gastric body was in normal anatomic position.

Hoff R. et al. (2017) [25] analyzed the case of a 76-year-old man was admitted to the hospital with epigastric pain radiating to the lower chest. His medical history included gastroesophageal reflux disease. Radiographic chest images demonstrated a large hiatal hernia. Nasogastric intubation resulted in drainage of 3 L of gastric secretions. Computed tomographic images without contrast demonstrated a large strangulated paraesophageal hernia. The patient underwent robotic-assisted laparoscopic repair of the hernia with surgical mesh. His postoperative course was complicated by sepsis, which resolved after a short course of cefepime.

Umemura A. et al. (2019) [26] presented the case of a 74-year-old female patient who presented with shortness of breath, chest pain, severe anorexia, and weight loss of 5 kg over the 3 previous months. Chest X-ray and CT examination revealed that her heart was retracted on the right side, and the hernia contents had induced physical compression of the left lung on the cranial side. A barium swallow test confirmed a diagnosis of hiatal hernia with UPD. On the basis of these findings, we performed a laparoscopic Nissen procedure, which resulted in the patient’s dramatic recovery. Postoperative examinations showed that the stomach and heart were once again normally located, and the left lung had reinflated. The patient was discharged after 5 days without any complication.

El Hajj Moussa W.G. et al. (2019 )[27] analyzed the case of an 88-year old woman presented with epigastric pain, hematemesis and food intolerance for the last two days and the case of a 91-year old patient was admitted for dyspnea and fever, with vomiting and food intolerance for the last 7 days. In both cases Chest X-ray showed a left thoracic opacity, and abdominal CT-scan images confirmed the diagnosis of gastric volvulus. The patients underwent a laparoscopic hernia reduction with sac excision, posterior cruroplasty and anterior gastropexy with continuous barbed suturing. For the first patient the postoperative course was uneventful, and follow-up showed complete resolution of her symptoms. For the second patient there were no surgical complications, but the patient died on the 4th day postoperatively due to respiratory failure.

Conclusion

from this data and our experience, we suggest prompt open surgery in cases of unstable patients. However, in case of gastric perforation or if there is any gastroscopic evidence of advanced gastric isch- emia in stable patients, an initial laparoscopic ap- proach is justifiable in case of adequate expertise, otherwise emergent open repair is suggested. For pa- tients with acute presentation but with out mechani- cal gastric obstruction and without gastric ischemia, we suggest a semi-elective repair.

References

1. Shafii A.E., Agle S.C., Zervos E.E. Perforated gastric corpus in strangulated paraesophageal hernia: a case report. J Med Case Rep. 2009; 3: 6507. DOI: https://doi. org/10.1186/1752-1947-3-6507.

2. Hill L.D., Tobias J.A. Paraesophageal hernia. Arch Surg. 1968; 96: 735-44.

3. Krahenbuhl L., Schafer M., Farhadi J., Renzulli P., Seiler C.A., Buchler M.W. Laparoscopic treatment of large paraesophageal hernia with totally intrathoracic stomach. J Am Coll Surg. 1998; 187: 231-7.

4. Tartaglia N., Iadarola R., Di Lascia A., Cianci P., Fersini A., Ambrosi A. What is the treatment of tracheal lesions associated with traditional thyroidectomy? Case report and systematic review. World J Emerg Surg. 2018; 13: 1-6. DOI: https://doi.org/10.1186/s13017-018- 0175-4.

5. Weber C., Davis C.S., Shankaran V., Fisichella P.M. Hiatal hernias: a review of the pathophysiologic theories and implication for research. Surg Endosc. 2011; 25: 3149-53.

6. Sanguedolce F., Landriscina M., Ambrosi A., Tartaglia N., Cianci P., Di Millo M., et al. Bladder Metastases from Breast Cancer: Managing the Unexpected. A Systematic Review. Urol Int. 2018; 101: 125-31. ISSN: 0042- 1138. DOI: https://doi.org/10.1159/000481576.

7. Tartaglia N., Di lascia A., Lizzi V., Cianci P., Fersini A., Ambrosi A., et al. Haemostasis in Thyroid Surgery: Collagen-Fibrinogen-Thrombin Patch versus Cellulose Gauze - Our Experience. Surg Res Pract. 2016; 2016: 3058754. ISSN: 2356-6124. DOI: https:// doi.org/10.1155/2016/3058754.

8. Curci J.A., Melman L.M., Thompson R.W., Soper N.J., Matthews B.D. Elastic fiberdepletion in the supportino ligaments of the gastroesophageal junction: a structural basis for the development of hiatal hernia. J Am Coll Surg. 2008; 207: 191-6.

9. Asling B., Jirholt J., Hammond P., Knutsson M., Walentinsson A., Davidson G., et al. Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia. Gut. 2009; 58: 1063-9.

10. Melman L., Chisholm P.R., Curci J.A., Arif B., Pierce R., Jenkins E.D., et al. Differential regulation of MMP-2 in the gastrohepatic ligament of the gastroesophageal junction. Surg Endosc. 2010; 24: 1562-5.

11. Hill L.D. Incarcerated paraesophageal hernia. A surgical emergency. Am J Surg. 1973; 126: 286-91.

12. Lebenthal A., Waterford S.D., Fiscichella P.M. Treatment and controversies in paraesophageal hernia repair. Front Surg. 2015; 2: 13. DOI: https://doi.org/10.3389/fsurg.2015.00013. PMID: 259 41675.

13. Tartaglia N., Cianci P., Di Lascia A., Fersini A., Am- brosi A., Neri V. Laparoscopic antegrade cholecystectomy: a standard procedure? Open Med. 2016; 11: 429-32. ISSN: 2391-5463. DOI: https://doi.org/10.1515/med- 2016-0078.

14. Cianci P., Fersini A., Tartaglia N., Ambrosi A., Neri V. Are there differences between the right and left laparoscopic adrenalectomy? Our experience. Ann Ital Chir. 2016; 87: 242-6. ISSN: 0003-469X.

15. Neri V., Ambrosi A., Fersini A., Tartaglia N., Cianci P., Lapolla F., et al. Laparoscopic cholecystectomy: evaluation of liver function tests. Ann Ital Chir. 2014; 85 (5): 431-7. ISSN: 0003-469X.

16. Neri V., Ambrosi A., Fersini A., Tartaglia N., Lapolla F. Common bile duct lithiasis: therapeutic approach. Ann Ital Chir. 2013; 84 (4): 405-10.

17. Schiergens T.S., Thomas M.N., Huttl T.P., Thasler W.E. Management of acute upside-down stomach. BMC Surg. 2013; 13: 55. DOI: https://doi. org/10.1186/1471-2482-13-55.

18. Ponte A., Pinho R., Viveiros F., Ferreira J., Tavares A., Fernandes C., et al. Incarcerated giant hiatal hernia. Endoscopy. 2014; 46 (Suppl 1): E561-2. DOI: https://doi. org/10.1055/s-0034-1377946. Epub 2014 Nov 19.

19. Martinez-Perez A., Garrigos-Ortega G., Gomez- Abril S.A., Torres-Sanchez T., Uceda-Navarro D. Perforated gastric volvulus due to incarcerated paraesophageal hernia. Rev Gastroenterol Mex. 2014; 79 (3): 204-6. DOI: https:// doi.org/ 10.1016/j.rgmx.2014.04.002. Epub 2014 May 24.

20. Di Saverio S., Smerieri N. Laparoscopic reduction and repair of a large incarcerated paraesophageal hernia. CMAJ. 2014; 186 (10): E400. DOI: https:// doi.org/10.1503/cmaj.131333.

21. Iqbal A., Naik R., Mohanan P.K. Gastric Gangrene Due to a Strangulated Paraesophageal Hernia-a Case report. Indian J Surg. 2015; 77 (Suppl 1): 66-8. DOI: https:// doi.org/10.1007/s12262-014-1135-1.

22. Díez Ares J.Á., Peris Tomas N., Estelles Vidagany N., Perianez Gomez D. Gastric necrosis secondary to strangulated giant paraesophic hiatal hernia. Rev Esp Enferm Dig. 2016; 108 (8): 498-500.

23. Gryglewski A., Kuta M., Pasternak A., Opach Z., Walocha J., Richter P. Hiatal hernia with upside-down stomach. Management of acute incarceration: case presentation and review of literature. Folia Med Cracov. 2016; 56 (3): 61-6.

24. Kiyani A., Khosla M., Anufreichik V., Chuang K.Y. "A Large HiatalHernia": Atypical Presentation of Gas- tric Volvulus. Clin Pract Cases Emerg Med. 2017; 1 (3): 187-9. DOI: https://doi.org/10.5811/cpcem.2017.2. 31075. eCollection 2017 Aug.

25. Hoff R., Qazi B. Strangulated Paraesophageal Hiatal Hernia. J Am Osteopath Assoc. 2018; 118 (3): 207. DOI: https://doi.org/10.7556/jaoa.2018.042.

26. Umemura A., Suto T., Fujiwara H., Ikeda K., Nakamura S., Hayano M., et al. Cardio pulmonary Impairments Caused by a Large Hiatal Hernia with Organoaxial Gastric Volvulus Showing Upside-Down Stomach: A Case Report. Am J Case Rep. 2019; 20: 1530-5. DOI: https:// doi.org/10.12659/AJCR.918191.

27. El Hajj Moussa W.G., Rizk S.E., Assaker N.C., Makhoul E.S., Chelala E.H. Large paraesophageal hernia in elderly patients: Two case reports of laparoscopic posterior cruroplasty and anterior gastropexy. Int J Surg Case Rep. 2019; 65: 189-92. DOI: https://doi.org/10.1016/ j.ijscr.2019.10.047.