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1 . 2015

Меthods of allogenic blood products decreasing in cardiac surgery

Abstract

Aim. The perioperative blood conservation management and decreasing of intraoperative bleeding for minimizing allogenic blood transfusion in cardiac surgery.

Methods. 467 adult patients underwent cardiac surgery in 2014 were analised. The next variables were studied: the volume of bleeding, the rate of red blood, fresh frozen plasma, autoplasma transfusion, the frequence of autohemotransfusion, the platelet function etc.

Main results. The volume of bleeding in coronary and valvular surgery did not exceeded 1000 ml. Allogenic red blood transfusion was performed only in 30–40% of patients. Auto plasma donation before operation was carried out in 70–90% of patiens. The frequency of autohemotransfusion up 1200 ml before bypass reached 60–70%. The reoperation of bleeding was reveald in 2.8% of pa- tiens. 70% patiens were operated without allogenic blood products.

Conclusion. The methods of deсreasing intraoperative blood loss by surgical and farmacological hemostasis in combination with the all methods of perioperative blood conservation permit to decrease donor blood transfusion during cardiac surgery with bypass without oxygen transport compromising.

Keywords:haemostasis, blood conservation, blood transfusion, reoperation for bleeding

Clin. Experiment. Surg. Petrovsky J. – 2015. – N 1. – Р. 57–65.

References

1. Babaev M.A. Syndrome of multiple organ failure after cardiovascular operations in conditions of assisted blood circulation: Diss. Moscow, 2011. (in Russian)

2. Bazylev V.V., Rasseykin E.V., Evdokimov M.E. Протокол кровесбережения при операциях с искусственным кровообращением. Byulleten Nauchnogo tseetra serdechno-sosudistoy khirurgii im. A.N. Bakuleva RAMN [Bulletin of the Scientific Center of Cardiovascular Surgery named after A.N. Bakulev, RAMS]. 2010; Vol. 11 (6): 218. (in Russian)

3. Bitkova E.E., Zvereva N.Yu., Khvatov V.B., Chumakov M.V., Timerbaev V.Kh., Dublev A.V., Redkoborodyi A.V. Whole blood co- agulation thromboelastometric profiles after cardiac surgery. Anesteziya i reanimatologiya [Anesthesiology and Intensive Care]. 2014; Vol. 1: 14–8. (in Russia)

4. Vinokurova S.A., Gorshkova N.N., Kryuchkov M.I. Transfusions of blood components to ensure the operations of myocardial revascularization. Materialy nauchno-prakticheskoy konferentsii «Aktual’nye voprosy ekstrakorporal’noy terapii [Proceedings of the scientific-practical conference “Actual problems of extracorporeal therapy”]. М., 2007. С. 112–3. (in Russian)

5. Rakhimov A.A., Bokeriya L.A. Skopin I.I. et al. Hardware reinfusion of red blood cells in cardiac surgery. Byulleten’ Nauchnogo tseetra serdechno-sosudistoy khirurgii im. A.N. Bakuleva RAMN [Bulletin of the Scientific Center of Cardiovascular Surgery named after A.N. Bakulev, RAMS]. 2012; Vol. 13 (6): 210. (in Russian)

6. Trekova N.A., Solovova L.E., Gus’kov D.A. et al. Transfusion therapy in operations on the heart and the aorta. Anesteziya i reanimatologiya [Anesthesiology and Intensive Care]. 2014; Vol. 3: 3–10. (in Russian)

7. Trekova N.A., Solovova L.E. Yavorovskiy A.G. et al. The implementation of modern principles of bloodless surgery in case of heart surgery with cardiopulmonary bypass Anesteziya i reanimatologiya [Anesthesiology and Intensive Care]. 2002. Vol. 5: 8–12. (in Russian)

8. Shevchenko Yu.L., Zhiburt E.B., Shestakov E.A. Implementation of blood saving technologies into practice of the Pirogov Center. Vestnik Natsional’nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova [Bulletin of N.I. Pirogov National Medical and Surgical Center]. 2008; Vol. 3 (1): 14–21. (in Russian)

9. Yavorovsky A.G., Zyulyaeva T.P., Charnaya M.A., Morozov Yu.A., Tolstova I.A., Gladysheva V.G., Bunyatyan A.A. The efficacy and safety of tranexamic acid and ε-aminocapronic acid at cardiac surgery under extracorporeal circulation. Anesteziya i reanima- tologiya [Anesthesiology and Intensive Care]. 2009; Vol. 4: 10–5. (in Russian)

10. Andreasen J., Sindby J., Brock B., et al. Efforts to change infusion practice and reduce transfusion rates are effective in CABG. J Cardiothorac Vasc Anesth. 2012; Vol. 26: 545–9.

11. Andreasen J., Detniersen C., Modrau I. et al: Storage time of allogenic red blood cells is associated with risk of severe postoperative infection after CABG. Eur Cardiothorac Surg. 2011; Vol. 39: 329–34.

12. Brown J., Birkmeyer N., Conner G. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation. 2007; Vol. 115: 2801–13.

13. Brevig J., Mc Donald J., Zelinga E. Blood transfusion reduction in cardiac surgery. Ann Thorac Surg. 2009; Vol. 87: 532–9.

14. Canadyova J., Zmeco D., Mocracek A. Re-exploration for bleeding of tamponade after cardiac operation. Interact Cardiovasc Thorac Surg. 2012; Vol. 14: 704–8.

15. Carrier M., Denault A., Lavoive J. Randomized controlled trial of pericardial blood processing with cell-saving device on neurologic markers in elderly patients after CABG. Ann Thorac Surg. 2006; Vol. 82: 51–5.

16. Casati V., Speciali G., Allessandro C. et al. Intraoherative low-volume acute normovolemic hemodilution in adult open-heart surgery. Anesthesiology. 2002; Vol. 97: 367–73.

17. Cardone D., Klein A.A. Perioperative blood conservation. Eur J Anaesthesiol. 2009; Vol. 26: 722–9.

18. Christensen M., Dziewior F., Kempel A. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth. 2012; Vol. 26: 46–51.

19. Djaiani G., Fedorko L., Borger M. et al. Continuous flow cell-saver reduces cognitive decline after CABG. Circulation. 2007; Vol. 116: 1888–95.

20. Dietrich W., Thueermel K., Yeyde S. et al. Aulogous blood donation in cardiac surgery. J Cardiothorac Vasc Anesth. 2005; Vol. 19: 589–596.

21. Karkouti K., Wijeysundera D., Yau T. et al. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion. 2004; Vol. 44: 1453–62.

22. Koch C., Duncan A. Transfusion in coronary bypass grafting is associated with reduced long-term survival. Ann Thorac Surg. 2006; Vol. 81: 1650–7.

23. Kochamba G., Pfeffer C., Sintek C. Intraoperative autotransfusion reduces blood loss after cardiopulmonary bypass. Ann Thorac Surg. 1996; Vol. 61: P. 900–3.

24. Kuduvali M., Newall N. et al. Effect of perioperative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery. Eur J Cardiothorac. Surg. 2005; Vol. 27: 592–8.

25. Murphy G., Reeves R., Rogers C. et al: Increased mortality, postoperative morbidity and cost after red blood cell transfusions in patients having cardiac surgery. Circulation. 2007; Vol. 116: 2544–52.

26. Nalla B., Freedman J., Hare G. Update on blood conservation for cardiac surgery. Cardiothorac Vasc Anesth. 2012; Vol. 26: 117–33.

27. Ranucci M. and EACTA. Perioperative haemostasis and coagulation management in cardiac surgery. Eur Anaesth. 2007; Vol. 24, suppl. 40: 1–13.

28. Scott B., Seifert F., Crimson R. Blood transfusion is associated with increased resource utilization, morbidity and mortality in cardiac surgery. Ann Card Anaesth. 2008; Vol. 11: 15–9.

29. Shander A., Moskowitz D., Rijhmani T. The safety and efficacy of bloodless cardiac surgery. Semin Cardiothorac Vasc Anesth. 2005; Vol. 9: 53–69.

30. Shander A., Fink A., Javidroozi M. et al. Appropriateness of allogenic red blood cell transfusion. Transfus Med Rev. 2011; Vol. 25: 232–46.

31. Snyder-Ramos S., Mohnle P., Weng E. et al. The ongoing variability in blood transfusion practice in cardiac surgery. Transfusion. 2008; Vol. 48: 1284–99.

32. The Society of Thoracic Surgeons Guideline. Perioperative blood transfusion and blood conservation in cardiac surgery. Ann Thorac Surg. 2011; Vol. 91: 944–82.

33. Spiess B.D. Transfusion of blood products affects out-come in cardiac surgery. Semin Cardiothorac Vasc Anesth. 2004; Vol. 8: 267–81.

34. Tanaka K., Bollige D., Vadlamudi R. et al. ROTEM-based coagulation management in cardiac surgery. J Cardiothorac Vasc Anesth. 2012; Vol. 26: 1083–93.

35. Vivacqua A., Coch C., Yousut A. et al. Morbidity of bleeding in cardiac surgery: it is blood transfusion, reoperation of bleeding or both. Ann Thorac Surg. 2011; Vol. 91: 1780–90.

36. Wang J., Ma H., Zheng H. Blood loss after cardiopulmonary bypass. A meta-analysis. Neth Med. 2013; Vol. 71: 123–7.

37. Whitson B., Yuddleston S., Savik K. et al. Risk of adverse outcomes associated with blood transfusion after cardiac surgery depends on the amount of transfusion. J Surg Res. 2010; Vol. 158: 20–7.

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CHIEF EDITOR
CHIEF EDITOR
Sergey L. Dzemeshkevich
MD, Professor (Moscow, Russia)

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