Mitral valve dysplasia as a component of dilated cardiomyopathy
Abstract Aim. Our objective was to study the incidence of mitral valve dysplasia combined with dilated cardiomyopathy by assessing long-term (5-year) results of organ-sparing reverse cardiac remodeling.
Methods. Reverse remodeling (uniting atrial and ventricular plasty, tricuspid valve reconstruction and mitral valve replacement with chordal preservation, CRT-D implantation) has been performed on 25 patients with dilated cardiomyopathy. All the patients underwent morphological studies of the myocardium of the right and left ventricles, histological analysis of the mitral valve leaflets.
Results. All the patients with a confirmed (clinically, immunologically, virologically, morphologically) diagnosis of dilated cardiomyopathy showed distinct histological features of mitral valve dysplasia: mucoid swelling, elastin breaks, lipomatosis.
Conclusion. The high frequency of the revealed combination of atrioventricular valve dysplasia with dilated cardiomyopathy may indicate consistency and uniformity of connective tissue lesions of both fibrous skeleton and myocardium in patients with dilated cardiomyopathy. We believe that this fact should serve as a serious warning to cardiologists identifying patients with dysplastic mitral insufficiency, as well as observing patients diagnosed with mitral valve prolapse without significant heart failure symptoms. Those patients may be at risk of developing delated cardiomyopathy.
Keywords:dilated cardiomyopathy, mitral valve dysplasia, prolapse, reverse cardiac remodeling
Clin. Experiment. Surg. Petrovsky J. 2015. № 2. Р. 18–24.
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