Renal allotransplantations from living related donors in patients with Alport syndrome
Abstract Aims. Appreciate results of related kidneys in patients with Alport syndrome and compare them with results of kidney transplantation in patients with renal hypoplasia.
Materials and methods. To carry out comparative analysis we utilized 8 patients with Alport and 27 patients with kidney hypoplasia. To execute this examination we utilized: cumulative survival by Caplan–Meyer, cumulative risk by Willcox, calculation grafts and patients losses.
Results. Comparative analysis has demonstrated, that level of patient and graft losses was almost equal in both groups. Practically equal were cumulative survival and cumulative risk.
Conclusion. In spite of development of anti-GBM-nephritis in patients with Alport syndrome, still results keep comparable with results of kidney transplantation in patients with other native diseases.
Keywords:renal transplantation, living related donor, Alport syndrome
Clin. Experiment. Surg. Petrovsky J. 2015. № 2. Р. 88–92.
References
1. Kashtan C.E., Michael A.F. Alport syndrome. Kidney Int. 1996; Vol. 50: 1445–63.
2. O’Neill W.M. Jr, Alkin C.L., Bloomer H.A. Hereditary nephri- tis: a re-examination of its clinical and genetic features. Ann Intern Med. 1978; Vol. 88: 176–82.
3. Hutson B.G., Kallun R., Gunvar S., et al. The pathogenesis of Alport syndrome involves type 1Y collagen molecules containing the alpha 3(IY) chain: evidence from anti-GBM-nephritis after renal transplantation. Kidney Int. 1992; Vol. 47: 179–87.
4. McCoy R.C., Johnson H.K., Stone W.J., et al. Absence of nephrogenic GMB antigen(s) in some patients with hereditary nephritis. Kidney Int. 1982; Vol. 21: 842–52.
5. Milliner D.S., Perides A.M., Holley K.E., et al. Renal transplantation in Alport’s syndrome: anti-glomerular basal membrane glomerulonephritis in the allograft. Mayo Clin. Proc. 1982; Vol. 57: 35–43.
6. Jeraj K., Kim Y., Vernier R.L., et al. Absence of Goodpasture’s syndrome antigen in male patients with familiar nephritis. Am J Kidney Dis. 1983; Vol. 2: 626–9.
7. Shah B., First M.R., Mendosa N.C., et al. Alport’s syndrome risk of glomerulonephritis induced of antiglomerular basement membrane antibody after renal transplantation. Nephron. 1988; Vol. 50: 34–8.
8. Byrne M.C., Bydisavijevic M.N. Fan Z., et al. Renal transplant in patients with Alport’s syndrome. Am J Kidney Dis. 2002; Vol. 39: 769–75.
9. Kaabak M.M., Sandrikov V.A., Raghimov A.A. Analysis of renal allografts survival with data of Russian register of dialysis society and possible ways for improvement of late results. Vestnik transplantologhii I iskusstvennykh organov [Bulletin of Transplantology and Artificial Organs]. 2006; N 4: 31. (in Russian)
10. Goryainov B.A., Kaabak M.M., Molchanova E.A. Plasmapheresis for treatment of perfusion damage in renal transplantation. An influence on instant and late postoperative period. Vestnik Rossiyscoy akademii meditzinskikh mauk [Bulletin of RAMS. ]2002; N 5: 43–5. (in Russian)
11. Kaabak M.M., Goryainov V.A., Zokoev A.K., Babenko N.N., Raghimov A.A., Salimov E.L., Solovjova I.N., Alekseeva L.A., Morozova M.M., Shyshlo L.A. Ten-years experience early plasmapheresis application after kidney transplantation. Vestnik transplantologhii I iskusstvennykh organov [Bulletin of Transplantology and Artificial Organs]. 2009; Vol. 11, N1: 28–33. (in Russian)
12. Goryainov V.A., Kaabak M.M., Babenko N.N., Zokoev A.K., Morozova M.M., Shishlo L.A. Allotransplantation of relative kidneys in children. Khirurghia. Zhournal im. N.I. Pirogova, [Surgery. The Journal named after N.I. Pirogov]. 2008; Vol. 6: 58–62. (in Russian)
13. Kaabak M.M., Babenko N.N., Zokoev A.K., Samsonov D.V. et al. Alemtuzumab induction in pediatric kidney transplantation. Pediatr Transplant. 2013; Vol. 17, N 2: 168–178.