The influence of mechanical characteristics of vascular patches on the formation of capsules
Abstract As a material for experimental studies were used new and used in practice samples vascular patches constituting the textile web. During our research it was noted that the thickness and bulk porosity vascular implants correlated inversely with the proportion of macrophages and thus their predecessors – monocyte cell layer connective tissue capsule. On the contrary, such characteristics as the surface density and mass of the sample correlated directly. That is precisely the values of these characteristics dacron prostheses in our experiment depended on the severity of the exudative phase of aseptic inflammation. It was also found that the thickness and surface density values correlated with the proportion of cells in series fibroblastic cell layer of connective tissue capsule.
Keywords:biocompatibility, capsule, physical and mechanical properties, surgical porosity, bulk porosity, surgical implant
Clin. Experiment. Surg. Petrovsky J. 2016. № 1. Р. 51–57.
References
1. Avtandilov G.G. Medical morphometry: a guide. Moscow: Meditsina, 1990: 384 р. (in Russian)
2. Alukhanyan O.A., Vinokur A.A., Gorbov L.V. Comparative characteristic of new models of vascular patches of polytetrafluoroethylene in the experiment. Angiologiya i sosudistaya khirurgiya [Angiology and Vascular Surgery]. 2012; Vol. 2: 45–51. (in Russian)
3. Novikov S. P., etc. Analysis of physical-mechanical and structural characteristics of artificial blood vessels Grudnaya i serdechno-sosudistaya khirurgiya [Thoracic and Cardiovascular Surgery]. 2012; Vol. 4: 27–33. (in Russian)
4. Biocompatibility. Under the editorship of V. I. Sevastyanov. Moscow, 1999: 368 р. (in Russian)
5. Byzov D.V., et al. Biotechnological aspects of creating grafts of arteries. Biotekhnologiya [Biotechnology]. 2010; Vol. 3 (3): 23–32. (in Russian)
6. Bokeriya L.A., Strizhakova L.L., Yushkevich T.I. The role of experimental studies in the development of new directions and innovative technologies. Byul. NTsSSKh im. A.N. Bakuleva [A.N. Bakoulev Scientific Center for Cardiovascular Surgery]. 2013; Vol. 14 (5): 4–11. (in Russian)
7. Vinokur A.A. Comparative study of new vascular patches of polytetrafluoroethylene (experimental study): Diss. Moscow, 2011: 101 р. (in Russian)
8. Zhukovsky V.A. New directions and opportunities for improving polymeric implants for reconstructive surgery. Modern technologies and possibilities of reconstructive and aesthetic surgery : materials of the II Intern. scientific. conf. Мoscow, 2010: 90–3. (in Russian)
9. Lazarenko S.V., et al. Distinctive features of the reaction of the tunica media and tunica intima of the aorta to the implantation of prostheses of various lavas. Kursk Scientific and practical bulletin "Man and his health". 2014; Vol. 4: 11–8. (in Russian)
10. Lipatov V. A., etc. Physico-mechanical and structural properties of implants designed for operations on the great vessels. Fundamental'nye Issledovaniya [Fundamental Research]. 2015; Vol. 11: 92–8. (in Russian)
11. Yasim A., Gul M., Ciralik H., Ergun Y. Gelatin-sealed Dacron graft is not more susceptible to MRSA infection than PTFE graft. Eur J Vasc Endovasc Surg. 2006; Vol. 32 (4): 425–30.
12. KaoW.J.,HiltnerA.,AndersonJ.M.,LodoenG.A.Theoretical analysis of in vivo macrophage adhesion and foreign body giant cell formation in strained poly (ether-urethane urea) elastomers. J Biomed Mater Res. 1994; Vol. 28: 819–29.
13. Yiannis K.N., Scotton C.J., MacKinnon A.C., Goldin R.D. et al. Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PloS One. 2014; Vol. 9 (1). Article ID e86241.