Phenotypes of resistance gram-negative non-fermentative bacteria isolated from children with congenital heart defects
Abstract Aim – to explore a range of sensitivity to antimicrobial agents of gram-negative non-fermentative bacteria isolated from children with congenital heart defects.
Material and methods. In the work we performed and analyzed the results of bacteriological examination of clini- cal material 775 patients аdmitted for treatment in 2015, using epidemiological, microbiological and statistical methods.
Results. The data indicate that the frequency of selection of bacteria among non-fermenting gram-negative micro- organisms amounted to 35.5%, which is prevalent among Pseudomonas aeruginosa (62,7%) with a high resistance to ceftazidime (84,4%), imipenem (50%), as well as the synthesis of metallo-β-lactamases in 46,9% of cases. The greatest number of isolates of Acinetobacter baumanii isolated from the respiratory tract (84,2 %) with high resistance to imipenem and ciprofloxacin (72,2%) and full resistance to amikacin. The majority of children, media resistant Pseudomonas aeruginosa and Acinetobacter baumanii detected during hospitalization (84%), which was early on hospital treatment and probably is hospital-acquired infection.
Conclusion. Microbiological monitoring is essential to ensure a rational choice of the initial empiric antimicrobial therapy, as well as for planning and implementation of measures for infection control.
Keywords:monitoring, non-fermentative gram-negative bacteria, children with congenital heart defects, stage of hospitalization, resistance
Clin. Experiment. Surg. Petrovsky J. 2016. № 2. Р. 47–50.
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