The genetics of mitral valve prolapse (analytical review)

Surgical correction of mitral valve (MV) insufficiency (plastics and prosthetics) is the second among the most frequent cardial valve pathology requires surgeries in Europe. Understanding of the MVP (mitral valve prolapse) genetic background is important for the prediction of MV progression and risk stratification in patients with this condition who need a surgery. Insights in molecular genetics gives a better understanding of MV anatomy and physiology, making the diagnosis of MV disorders more effective, accurate and reliable. In this review we overlook hereditary diseases with MVP as a part of clinical phenotype. Most of these disorders are characterized by multisystem damage (always with progressive course of the desease). Patients expose such symthoms as dilatation of phyber rings, prolapses, chordes ruptures with reguritation, and failure of the central hemodynamics. In this review we analyse data published in this field since 2000 up to 2013.