Value of the procalcitonin in cardiosurgery practice
Abstract
Determination of procalcitonin (PCT) concentration is the gold standard in the diagnosis of
sepsis. Retrospectively an analysis of PCT level, number of leukocytes in peripheral blood
and an etiology of bacteremia in 70 patients (20 children, 50 adults) with congenital and
acquired heart defects and with coronary heart disease was carried out. The number of leucocytes (WBC×109/L) in peripheral blood was determined by a flowing cytofluometry on the
automatic hematology analyzer “Sysmex XT 2000i” (Sysmex Corporation, Japan). The PCT serum
concentration (pg/ml) was determined by an electrochemiluminescent method on the immunochemical analyzer “Cobas c 411” (Roche Diagnostics, Germany). Revealing, identification
and detection of the microorganisms sensitivity to antibacterial drugs in biological material
(blood, washings from the tracheobronchial tree, urine) was carried out on bacteriological
analyzers “Vitek 2 Compact 30” and “Bact/Alert 3D 60” (BioMerieux, USA). The study of PCT
levels in cardiosurgical patients with complicated postoperative periods made it possible to
draw the following conclusions: the procalcitonin level in cardiosurgical patients with infectious and inflammatory process (sepsis) varied from 2.0 to 79.22 ng/ml. It is not possible to
diagnose sepsis with a procalcitonin level above 79.23 ng/ml in cardiosurgical patients with
complicated postoperative period in the first day after surgery. It is necessary to monitor the
procalcitonin level dynamically along with a microbiological study. By the procalcitonin level
it is difficult to assess the course of the complicated postoperative period. It is necessary to
determine the procalcitonin level in dynamics. A decrease in the procalcitonin level on the
background of the current therapy indicates a favorable course of the postoperative period and
the effectiveness of the therapy.
Keywords:procalcitonin, sepsis, infection, heart surgery
Clin. Experiment. Surg. Petrovsky J. 2018; 1 (19): 51–61.
DOI: 10.24411/2308-1198-2018-00008
Received: 15.12.2017. Accepted: 25.01.2018.
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