Properties and clinical diagnostic value of lactoferrine and ferritin assessment in acute pancreatitis
Abstract
Background. The part of acute pancreatitis in the structure of surgical diseases constantly grows every year, despite the highest level of modern technological capabilities. Studies of the acute phase of proteins clarifies their unique role in various pathologies. Assessment of two acute phased proteins – lactoferrin and ferritin – demonstrated to be very useful in diagnostics of acute pancreatitis.
Aim of the study – determination of clinical-diagnostic and predictive value of level of a laсtoferrin and ferritin in blood serum of patients with acute pancreatitis.
Material and methods. 106 patients with various forms of acute pancreatitis and 41 donors were examined. By means of the immunofermental analysis the dynamic routine retrospective of laсtoferrin and ferritin level of blood serum in patients with acute pancreatitis was conducted.
Results. We found correlation between the level of ferritin and laсtoferrin and development of destructive processes in the pancreas at acute pancreatitis was found. Based on this result the coefficient was offered: 10 and less means the lack of destruction, 11–15 means localized destruction, 16–20 – widespread purulent – destructive process, and more than 20 means poor outcome of the disease.
Conclusion. Assessment of ferritin and laсtoferrin concentrations in blood serum of patients with acute pancreatitis has not only clinical-diagnostic value, but also allows to estimate severity of patient’s condition, adequacy and efficiency of the used therapy and also has prognostic value for the development of complications.
Study design: the level of evidence IIa.
Keywords:acute pancreatitis, pancreatic necrosis, acute phase proteins, ferritin, lactoferrin
Clin Experiment Surg. Petrovsky J. 2018; 6 (4): 55–61.
doi: 10.24411/2308-1198-2018-14008. Received: 01.09.2018. Accepted: 24.10.2018.
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