Diversion colitis syndrome in multi-stage surgery (experimеtntal study)
Abstract
The aims – to optimize the rehabilitation program for the patients with colostomy in multistage surgery on a large intestine with an evaluation of the structural and functional changes in the intestinal wall with diversion colitis and after its correction in experiment.
Material and methods. We described new method of diversion colitis prophylaxis and treatment (Patent of Russian Federation # 2544340 from 20.02.2014) with the use of the dihydroquercitin (DHQ) solution. We used 60 white laboratory rats both male and female. All rats were passed through surgery with double-barreled colostomy creation. All rats were divided for 3 groups by randomization with random number method with the use special software. The main group was consist of 20 rats with the prophylaxis of the DC by described method with DHQ. Control-1 group consisted of 20 rats with prophylaxis of the DC by camomile infusion instillation. The control-2 group – 20 rats with colostomy without any prophylaxis methods of the DC usage. All experimental rats were mortified in 6 months with subsequent histological investigation by thin and ultra-thin microscopy.
Results. The DC can be characterized by deep structural and functional disturbances of the diversion parts of the large intestine. The chamomile infusion didn’t show significant effect for intestinal wall structure preservation – it decreased the level of inflammation but don’t fight against proliferative cell infiltration. DHQ stabilizes the compensatory adaptive reactions in every intestinal membranes.
Conclusion. The method of DC prophylaxis by DHQ usage has high effectiveness for preservation of the structural and functional organization of the intestinal wall.
Keywords:dixydroquercitin, diversion colitis, intestinal wall
For citation: Anikin S.V., Tseluyko S.S., Yanovoy V.V., Tashkinov N.V. Diversion colitis syndrome in multi-stage surgery (experimеtntal study). Clin Experiment Surg. Petrovsky J. 2019; 7 (2): 38–46. doi: 10.24411/2308-1198-2019-12005. (in Russian)
Received 01.04.2019. Accepted 22.04.2019.
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