Breast density as a risk factor of development of ductal carcinoma in situ
Abstract
Aim – to reveal a potential relationship between the breast density, various radiographic patterns of the breast structure, and the risk of developing of ductal adenocarcinoma in situ.
Methods. In this study, 169 patients were divided into 2 groups according to the modern X-ray classification offered by L. Tabar. All patients underwent a core biopsy with subsequent histological examination. The 1st group consisted of 57 (33.7%) women with tumors arising in the terminal ductal-lobular unit – acinar adenocarcinoma (AAB), unifocal and multifocal forms, and the 2ndgroup – 112 (66.3%) women with ductal adenocarcinoma in situ (in situ DAB) and ductal adenocarcinoma in situ associated with the acinar form of breast cancer (DAB + AAB). Pathologic findings on mammography were assessed according to the modern classification of L. Tabar. Evaluation of the breast density was made using ACR 2013 classification. The Pattern of radiologic breast structure was evaluated according to the classification of L. Tabar.
Results. Our results demonstrated statistically significant differences between compared groups on the breast density (p<0.001). In the 1st group, patients with density of ACR 1 prevailed (52.6%). The incidence of ACR 4 was the highest in the 2nd group (32.1%). Thus, it was concluded that breast density ACR 3 and ACR 4 is associated with the risk of DAB development.
Conclusion. High breast density, as well as the IV and V type of the breast structure according to L. Tabar’s classification, are statistically associated with an increased risk of developing ductal carcinoma in situ (DAB). Our study also showed a statistically significant difference in the age of onset of ductal and acinar adenocarcinoma of the breast – 52 and 64 years respectively.
Keywords:breast density, mammography, ductal adenocarcinoma in situ
For citation: Puchkova O.S., Sinitsyn V.E., Bogomazova S.Yu., Shirokiy V.P., Mershina E.A., Bazhenova D.A., Nenaydenko E.V. Breast density as a risk factor of development of ductal carcinoma in situ. Clin Experiment Surg. Petrovsky J. 2019; 7 (2): 53–9. doi: 10.24411/2308-1198-2019-12007. (in Russian)
Received 22.10.2018. Accepted 22.04.2019.
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