Effect of antibacterial therapy on the barrier function of the intestinal wall
Abstract
Enteric intestinal insufficiency accompanies the majority of severe surgical diseases, where as the underlying disease progresses, the intestine itself becomes a powerful source of endogenous intoxication. Assigned in a complex therapy of antibiotics due to the effect on the intestinal microbiota, affect the wall of the bowel. Therefore, the study of the isolated effect of antibacteri-al therapy on the barrier function of the intestinal wall will allow us to study in depth the funda-mental mechanisms of the development of enteric insufficiency of the intestine under the influ-ence of an antibiotic.
The study was carried out on Wistar rats. Control series (n=50) – live daily, for 10 days intra-muscularly injected saline. Experimental series (n=50) – animals daily, for 10 days intra-muscle injected ceftriaxone. The follow-up periods are 1, 5, 10, 15, 20 and 30 days.
The study established the development of barrier intestinal wall dysfunction against a back-ground of 10-day antibacterial therapy, which was accompanied by the development of the syn-drome of endogenous intoxication and the formation of destructive processes in the mucosa of the large intestine (p<0.001).
After the abolition of antibacterial therapy for 10 days (p<0.001) due to barrier dysfunction of the intestinal wall, the intestine itself becomes the source of endogenous intoxication.
The presence of high tightness of correlation correlation r=0.74 (p<0.05) between destructive processes in the intestinal wall and endogenous intoxication was established.
Keywords:antibacterial therapy, endogenous intoxication, barrier function of the intestinal wall, enteric insufficiency syndrome, intestinal microbiota
For citation: Suslov A.V., Mitroshin A.N., Solomakha A.A., Galkina N.G., Suslova I.S., Grishina I.А., Chairkin I.N. Effect of antibacterial therapy on the barrier function of the intestinal wall. Clin Experiment Surg. Petrovsky J. 2019; 7 (4): 78–83. doi: 10.24411/2308-1198-2019-14010 (in Russian)
Received 10.10.2018. Accepted 31.10.2019.
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