Long-term results as an indicator of fundamental problems in cardiac transplantology
clinical experience in the field of orthotopic heart transplantation already
has more than 50 years of history. In Russia, the first successful series of
such operations was performed by V.I. Shumakov. Here we present a result
of the first long-term result of such an operation, exceeding three decades of
life with a heart transplant, and analysis of the causes of success and the resulting
diagnostic and treatment problems.
Keywords:dilated cardiomyopathy, cardiogenetics, orthotopic heart transplantation, long-term results in transplantology, post-transplantation cardiomyopathy
Funding. The study was carried out with
partial support from the Russian Science Foundation grant No. 16-15-10421.
Conflict of interests. The authors declare no
conflict of interests.
For citation: Dzemeshkevich S.L., Trekova
N.A., Babaev M.A., Chaus N.I., Lokshin L.S., Frolova Ju.V., Dombrovskaya A.V.,
Zaklyazminskaya E.V. Long-term results as an indicator of fundamental problems
in cardiac transplantology. Clinical and Experimental Surgery. Petrovsky
Journal. 2020; 8 (3): 22-6. DOI: https://doi.org/10.33029/2308-1198-2020-8-3-22-26 (in Russian)
1. Barnard Ch.N. The operation. A human cardiac transplant: an interior report of a successful operation performed at Groote Seheur Hospital Cape Town. S Afr Med J. 1967; 41: 1271-4.
2. Demikhov V.P. Vital organ transplant in experiment. Moscow, 1960. (in Russian)
3. Calne Roy. A brief history of clinical organ transplantation. Clinical and Experimental Surgery. Petrovsky Journal. 2017; 3: 7-17.
4. Kirklin J.K. Transplantation and mechanical support of the application. Clinical and Experimental Surgery. Petrovsky Journal. 2017; 3: 22-7.
5. Richards S., Aziz N., Bale S., et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015; 17 (5): 405-24. DOI: https://doi.org/10.1038/gim.2015.30
6. Dzemeshkevich S.L., Stephenson L.W. Myocardial dysfunction and heart surgery. Moscow, GEOTAR-Media, 2009: 317 p. (in Russian)
7. Dzemeshkevich S., Ragimov A., Mikhaylov Yu. et al. Plasmapheresis in the treatment of posttransplant cardiomyopathy. Artif Organs. 1998; 22 (3): 197202.
8. Dzemeshkevich S.L.,TsyplenkovaV.G., FrolovaYu.V., et al. post-transplantation cardiomyopathy: energy-producing particle of cardiomyocytes at the terms up to 25 years of ortotopic heart transplantation. Rossiyskiy kardiologicheskiy zhurnal [Russian Journal of Cardiology]. 2015; 11 (27): 42-5. (in Russian)
9. Khush K.K., Patel J., Pinney S., et al. Noninvasive detection of graft injury after heart transplant using donor-derived cell-free DNA: a prospective multicenter study. Am J Transplant. 2019; 19 (10) 2889-99. DOI: https://doi.org/10.1111/ajt.15339