Myocardial biopsy in the differential diagnosis of the syndrome of dilated cardiomyopathy: clinicopathological study

• Evgeniya A. Kogan
• Olga V. Blagova

Abstract

To explore the possibilities of a morphological analysis of myocardial biopsy specimens in the differential nosological diagnosis of DCM. 42 (12 female and 30 male) patients with DCM underwent clinical examination; LVEDD – 6,8±0,9 cm, LA – 5,0±0,7 cm, RV – 3,4±0,7cm, EF – 25,9±11,1%. During right ventricular endomyocardial biopsy 5–6 regions of myocardium were investigated; during intraoperative biopsy we looked at the state of the papillary muscles and left ventricular wall. All four cardiac chambers were explored in 9 patients. Virusimmune myocarditis was diagnosed in 28 patients, DCM proper – in 4, arrhythmogenic right ventricular cardio- myopathy – in 2, noncompacted myocardium – in 6 and cardiac amyloidosis – in 1 patient. Nosological diag- nosis made on the basis of in vivo morphological study of the myocardium of patients with DCM, can serve as a basis for differentiated drug therapy and the choice of method of surgical treatment.

Keywords:myocardium, biopsy, syndrome of dilated cardiomyopathy

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