Use of polypropylene explants in gastrostomia in experiment

• Vaganov A.G.
• Oleg N. Antonov
• Kosenkov A.N.
• Stulov E.S.

Abstract

Enzyme systems, cellular features, the functioning of the digestive tube obey the conveyor principle, therefore, interference in the work of the digestive system during gastrostomy, in addition to surgical complications, is accompanied by the consequences of violation of this principle, which determines the relevance of the study.

Aim – to develop a gastrostomy method that reduces the risk of complications by using a mesh.

Material and methods. Prospective experimental study in 18 rabbits. The main group (n=6) – gastrostomy by the author’s method. 1^st comparison group (n=6) – Witzel gastrostomy and 2^nd comparison group (n=6) – Depage–Janeway gastrostomy using the GIA apparatus. For histological studies and morphometry, 5 animals were bred from each group on days 10 and 20.

Results. Microcirculation disorders and necrosis in the area of sutures (with gastrostomy according to Witzel and Depage–Janeway) are leveled by using a mesh. More pronounced morphological changes in the form of microenvironment necrosis and stagnant microcirculation disorders occurred after operations without using a mesh.

Conclusion. The use of a mesh causes tissue rearrangements due to fibrillogenesis, which contributes to more reliable fixation of the gastrostomy, and a decrease in the mechanical load on the ligatures.

Keywords:gastrostomy; polypropylene prosthesis

References

1. Pavelets K.V. A new method of gastrostomy as a stage of surgical treatment burns of the esophagus. Vestnik khirurgii imeni I.I. Grekova [Bulletin of Surgery named after I.I. Grekov]. 2012; 171 (4): 68–70. (in Russian)

2. Kawahara H. Can laparoscopic antireflux surgery improve the quality of life in children with neurologic and neuromuscular handicaps. J Pediatr Surg. 2004; 39 (12): 1761–4.

3. Angsten G., Danielson J., Kassa A.M., Lilja H.E. Outcome of laparoscopic versus open gastrostomy in children. Pediatr Surg Int. 2015; 31: 1067–72.

4. Fox D., Campagna E.J., Friedlander J., Partrick D.A.,  Rees D.I., Kempe A. Nationaltrends and outcomes of pediatric gastrostomy tube placemen. J Pediatr Gastroenterol Nutr. 2014; 59: 582–8.

5. Vasseur M.S., Reinberg O. Laparoscopic technique to perform a true Stamm gastrostomy in children. J Pediatr Surg. 2015; 50: 1797–800.

6. Baranovsky A.Yu., Timofeeva N.M. The scientific basis of nutrition for a healthy and sick person. Vestnik Sankt-Peterburgskoy meditsinskoy akademii poslediplomnogo obrazovaniya [Bulletin of the Saint Petersburg Medical Academy of Postgraduate education]. 2010; 2 (1): 66–82. (in Russian)

7. Desyatnichenko K.S., Leont’ev V.K. On the mechanism of interrelation of the oral phase digestion, the state of the oral cavity and gastric secretion. Institut stomatologii [Institute of Dentistry]. 2007; 3 (36): 102–3. (in Russian)

8. Kostyuchenko L.N., Kostyuchenko M.V., Smirnova O.A.  metabolic complications in parenteral enteral nutrition. Eksperimental’naya i klinicheskaya gastoenterologiya [Experimental and Clinical Gastroenterology]. 2015; 8 (120): 51–5. (in Russian)

9. Hollander F. The gastric pouch from its origins to the present; an historical study in the methodology of gastric physiological contributions of Pavlov. J Mt Sinai Hosp N Y. 1951; 17 (6): 872–85. PMID: 14814509.

10.   Tonkikh A.V. Pavlov’s theory on digestion and its significance in medicine. Sov Vrachebnyi Sb 1949; 17: 7–12. PMID: 15418378.

11.   Gottschalk A., Strotzer M., Feuerbach S., Rogler G., Seitz J., Völk M. CT-guided percutaneous gastrostomy: success rate, early and late complications. Rofo. 2007; 179 (4): 387–95.

12.   Hucl T., Spicak J. Complications of percutaneous endoscopic gastrostomy. Best Pract Res Clin Gastroenterol. 2016; 305: 769–81. DOI: https://doi.org/10.1016/j.bpg.2016.10.002  

13.   Park S.K., Kim J.Y., Koh S.J., Lee Y.J., Jang H.J., Park S.J.; Small Intestine and Nutrition Research Group of the Korean Association for the Study of Intestinal Diseases (KASID). Surg Endosc. 2018; Aug 21. DOI: https://doi.org/10.1007/s00464-018-6339-1   

14.   Zavyalova A.N., Gostimsky A.V., Lisovsky O.V., Gavshchuk M.V., Karpatsky I.V., Pogorel’chuk V.V., et al. Enteral nutrition in palliative medicine in children. Pediatriya [Pediatrics]. 2017; 8 (6): 105–13. (in Russian)

15.   Kozlov Yu.A. Laparoscopic gastrostomy in young children. Detskaya khirurgiya [Pediatric Surgery]. 2013; (3): 16–20.  (in Russian)

16.   Kozlov Yu.A., Novozhilov V.A., Rasputin A.A., et al. Comparison of methods gastropexy during laparoscopic gastrostomy in newborns and infants. Detskaya khirurgiya [Pediatric Surgery]. 2017; 21 (5): 234–8. (in Russian)

17.   Mitupov Z.B. Minimally invasive interventions in thoracic surgery childhood: Autoabstract of Diss: 14.01.19. Moscow, 2010: 47 p. (in Russian)

18.   Ovchinnikova I.G., Lazareva L.A., Borchaninova Yu.V. Nutritive features support of patients in the conditions of the surgical department. Mezhdunarodniy nauchno-issledovatel’skiy zhurnal [Research Journal of International Studies]. 2016; 4–5 (46): 117–9. (in Russian)

19.   Reshetov I.V., Egorov G.N. Preoperative nutritional therapy for patients with tumors of the head and neck. Zhurnal Obshcherossiyskoy obshchestvennoy organizatsii «Federatsiya spetsialistov po lecheniyu zabolevaniy golovy i shei» [Journal  of the All-Russian Public Organization Federation of Specialists in the Treatment of Head and Neck Diseases]. 2013; (2): 27–34. (in Russian)

20.   Zamolodchikova T.S. Serine proteases in the small intestine mucosa localization, functional properties, physiological role review. Biokhimiya [Biochemistry]. 2012; 77 (8): 989–1001.  (in Russian)

21.   Kuznetsov V.M. Fundamentals of scientific research in animal husbandry. Kirov: Zonal’niy NIISKh Severo-Vostoka, 2006: 568 p. (in Russian)

22.   Razina A.V., Frolova A.I., Sergeev M.A. Optimization of the method of general anesthesia on rabbits. Aktual’nye voprosy veterinarnoy biologii [Topical Issues of Veterinary Biology]. 2010;  1 (5): 3–8. (in Russian)

23.   Grigoryuk A.A., Kovalev V.A. The use of mesh polypropylene implants in the treatment of postoperative ventral hernias: an experimental and clinical study. Dal’nevostochniy meditsinskyy zhurnal [Far Eastern Medical Journal]. 2010; (2): 23–6. (in Russian)

24.   Sidorova K.A. Morphology of the stomach of rabbits and their qualitative indicators products. Agrarniy vestnik Urala [Agrarian Bulletin of the Urals]. 2013; (3): 30–2. (in Russian)

25.   Mishina E.S., Zatolokina M.A., Netyaga A.A., Klimova L.G., Zhukovsky V.A. Reactive changes in the connective tissue of the anterior abdominal wall in the early postoperative period when using prototype mesh endoprostheses with an antibacterial coating. Sovremennye problemy nauki i obrazovaniya [Modern Problems of Science and Education]. 2015; (2): 55. (in Russian)

26.   Bontsevich D.N., Golubev O.A. The use of improved suture material in experiment. Problemy zdorov’ya i ekologii [Problems of Health and Ecology]. 2004; (2): 141–4. (in Russian)

27.   Qu S., Xia J., Yan J., Wu H., Wang H., Yi Y., et al. In vivo and in vitro assessment of the biocompatibility and degradation of high-purity Mg anastomotic staples. J Biomater Appl. 2017; 31 (8): 1203–214. DOI: https://doi.org/10.1177/0885328217692948   

28.   Wang Z.G., Huang Y.D., Cheng K.L., Cai X.B., Wu Z., Zhan J.D.  Influence of blood supply of the esophageal and gastric stumps on anastomotic healing after esophagogastrostomy in rabbits. Di Yi Jun Yi Da Xue Xue Bao. 2004; 24 (3): 345–6, 51.

29.   Vinogradov S.Yu., Krishtop V.V., Dindyaev S.V., Torshilova I.Yu. Experience application of the teaching aid «Graphological structure of the course of frequent histology». Sovremennye problemy nauki i obrazovaniya [Modern Problems of Science and Education]. 2009; (1): 45. (in Russian)

30.   Markos’yan S.A., Vlasov A.P. Experimental assessment of changes in tissues double-row small bowel anastomosis at different ages. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. [Proceedings of Higher Educational Institutions. Volga Region]. 2018; 1 (45): 18–26. (in Russian)

31.   Bazmara H., Soltani M., Raahemifar K., Sefidgar M., Bazargan M., Naeenian M.M., et al. Activation of apoptotic signal in endothelial cells through intracellular signaling molecules blockade in tumor-induced angiogenesis. Biomed Res Int. 2015; 2015: 908757. DOI: https://doi.org/10.1155/2015/908757

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