Influence of segmental autotransplantation of pancreas on its endocrine and exocrine functions

• Sergey E. Voskanyan
• I.N. Korsakov
• E.V. Naydenov
• V.S. Degtyarev

Abstract

Aim – to study the influence of transplantation of the segment of the pancreas at the endocrine and exocrine pancreatic secretion. Material and methods. The research has been performed to 48 animals. Endocrine and exocrine functions of the pancreas have been studied after proximal resection of the pancreas (1 group), pancreatectomy with autologous transplantation of the pancreas and with reconstruction of the venous outflow from the transplant into the inferior vena cava (2 group) and pancreatectomy with autologous transplantation of the pancreas and with reconstruction of the venous outflow from the transplant into the portal vein (3 group). Examining the status of carbohydrate metabolism was performed by intravenous test for glucose tolerance. Glucose tolerances at the oral and intravenous load, insulin and glucagon concentrations in the blood serum, and debits of the protein production and lipase secretion in the pancreatic secretion have been studied. Results. Trasplant segment of the pancreas on condition of the formation of the venous outflow in the portal system is able to ensure the maintenance of homeostasis of carbohydrate at an acceptable level under lower load on endocrine unit transplant. A significant reduction of the secretory response to nutritional stimulation has been observed in animals after pancreatectomy with segmental autotransplantation of the pancreas, compared with animals that had proximal resection of the pancreas. No reduction in flow rates of the secretion in response to the introduction of duodenal trypsin in small doses was found, while the adaptability of the secretion to the nutritional composition of duodenal contents and the reaction to the introduction of duodenal trypsin remained at high doses were saved.

Keywords:segmental pancreas transplantation, diabetes mellitus, exocrine pancreatic secretion, endocrine pancreatic secretion, carbohydrate metabolism

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