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2 . 2022

The use of non-steroidal anti-inflammatory drugs for the prevention of chronic postoperative pain


Chronic postoperative pain significantly reduces the quality of life of patients and the effectiveness of surgical treatment. In this article, the authors consider a differentiated approach to the use  of non-steroidal anti-inflammatory drugs in order to prevent chronic postoperative pain.

Keywords:chronic postoperative pain; factors of chronic postoperative pain; non-steroidal anti-inflammatory drugs; prevention of postoperative pain

Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Medvedeva L.A., Zagorulko O.I., Churyukanov M.V. The use of non-steroidal anti-inflammatory drugs for the prevention of chronic postoperative pain. Clinical and Experimental Surgery. Petrovsky Journal. 2022; 10 (2): 120–5.  DOI:   (in Russian)


1. Raja S.N., Carr D.B., Cohen M., Finnerup N.B., Flor H., Gibson S., et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020; 161 (9): 1976–82. DOI:  

2. Yakhno N.N., Kukushkin M.L., Churyukanov M.V., Davydov O.S., Bakhtadze M.A. New definition of pain by the international association for the study of pain. Rossiyskiy zhurnal boli [Russian Journal of Pain]. 2020; 18 (4): 5–7. DOI:  (in Russian)

3. Bonica J.J. The need of a taxonomy – pain terms: a list with definitions and notes on usage. Pain. 1979; 6: 247–52.

4. Macrae W.A, Davies H.T. Chronic postsurgical pain. In: I.K. Crombie, S. Linton., P. Croft, M. Von Korff, L. LeResche (eds). Epidemiology of Pain. Seattle: IASP Press, 1999: 125–42.

5. Kehlet H., Edwards R. Persistent postoperative pain: pathogenic mechanisms and preventive strategies. In: I. Tracey (ed.). Pain 2012. 14th World Congress of Pain. Seattle: IASP Press, 2012: 133–46.

6. Zagorul’ko O.I., Medvedeva L.A., Churyukanov M.V. Chronic postoperative pain. Khirurgiya. Zhurnal imeni N.I. Pirogova [Surgery. The Journal  Named after N.I. Pirogov]. 2021; (6-2): 84–8. DOI: (in Russian)

7. Shevtsova G., Churukanov M., Medvedeva L., Zagorulko O.,  Malenkova Y. Failed back surgery syndrome – a case, demonstrating a significant role of cognitive psychotherapy in a complex FBSS treatment. Eur J Anaesthesiol. 2019; 36 (S57): 201.

8. Wu C., Raja S. Treatment of acute postoperative pain. Lancet. 2011; 377 (9784): 2215–25. DOI:  

9. Crombie I.K., Davies H.T., Macrae W.A. Cut and thrust: antecedent surgery and trauma among patients attending  a chronic pain clinic. Pain. 1998; 76 (1–2): 167–71.

10.   Bayman E.O., Brennan T.J. Incidence and severity of chronic pain at 3 and 6 months after thoracotomy: meta-analysis. J Pain. 2014; 15: 887–97. DOI:  

11.   Wang L., Cohen J.C., Devasenapathy N., Hong B.Y., Kheyson S., Lu D., et al. Prevalence and intensity of persistent post-surgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies. Br J Anaesth. 2020; 125 (3): 346–57. DOI:   

12.   Hoofwijk D.M., Fiddelers A.A., Peters M.L., Stessel B., Kessels A.G., Joosten E.A., et al. Prevalence and predictive factors of chronic postsurgical pain and poor global recovery 1 year after outpatient surgery. Clin J Pain 2015; 31: 1017–25. DOI:  

13.   Macrae W.A. Chronic post-surgical pain: 10 years on. Br J Anaesth. 2008; 101 (1): 77–86. DOI:  

14.   Schug S.A., Bruce J. Risk stratification for the development of chronic postsurgical pain. Pain Rep. 2017; 312 (6): e627. DOI:  

15.   Gerbershagen H.J. Transition from acute to chronic postsurgical pain. Physiology, risk factors and prevention [in German]. Schmerz. 2013; 27: 81–93. DOI:   

16.   Van Den Kerkhof E.G., Peters M.L., Bruce J. Chronic pain after surgery: time for standardization? A framework to establish core risk factor and outcome domains for epidemiological studies. Clin J Pain. 2013; 29: 2–8. DOI:  

17.   Ovechkin A.M., Bayalieva A.Zh., Ezhevskaya A.A., Eremenko A.A., Zabolotsky D.V., Zabolotskikh I.B., et al. Postoperative analgesia. Guidelines. Vestnik intensivnoy terapii imeni A.I. Saltanova [Bulletin of Intensive Care named after A.I. Saltanov]. 2019; (4): 9–33. DOI: 4-9-33  (in Russian)

18.   Chou R., Gordon D.B., de Leon-Casasola O.A., Rosenberg J.M., Bickler S., Brennan T., et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016; 17 (2): 131–57. DOI:  

19.   Meara A.S., Simon L.S. Advice from professional societies: appropriate use of NSAIDs. Pain Med. 2013; 14 (S1): 3–10. DOI:  

20.   Nise: instructions for use. URL: (in Russian)

21.   Nemtsov B.F., Shilkina I.A. Nimesulide (Nise) influence on blood serum prostaglandin E2 concentration and cardiovascular system function in patients with rheumatoid arthritis. Nauchno-prakticheskaya revmatologiya [Rheumatology Science and Practice]. 2009; 47 (5): 18–23. URL:  (in Russian)

22.   Benett A., Villa G. Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities. Expert Opin Pharmacother. 2000; 1: 277–86. DOI:   

23.   Bianchi M., Martucci C., Ferrario P., Franchi S., Sacerdote P. Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs. Anesth Analg. 2007; 104 (4): 949–54. DOI:  

24.   Kriegel W., Korff K.J., Ehrlich J.C., Lehnhardt K., Macciocchi A., Moresino C., et al. Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. Int J Clin Pract. 2001; 5 (8):  510–4.

25.   Ovechkin A.M. Non-steroidal anti-inflammatory drugs in anesthesiology and surgery. Regionarnaya anesteziya i lechenie ostroy boli [Regional Anesthesia and Treatment of Acute Pain]. 2009; 3 (2): 5–14. (in Russian)

26.   Sidel’nikov P.V., Chub V.V. Ways to improve the quality of anesthesia during osteoplastic surgery with dental implantation. Sovremennaya stomatologiya [Modern Dentistry]. 2008; (2): 29–32. (in Russian)

27.   Costa F.W.G., Soares E.C.S., Esses D.F.S., deB Silva P.G.,  Bezerra T.P., Scarparo H.C., et al. A split-mouth, randomized, tripleblind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. Int J Oral Maxillofac Surg. 2015; 44: 1166–74. DOI:  

28.   De Oliveira G.S. Jr, Agarwal D., Benzon H.T. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg. 2012; 114 (2): 424–33. DOI: 34d68  

29.   Santos B.F.E., Costa F.O., Vasconcelos A.M.A., Cyrino R.M., Cota L.O.M. Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries: a randomized placebo-controlled split-mouth clinical trial. J Periodontol. 2021; 93 (2): 300–9. DOI:  

30.   Bertelli E., Pelliccioni G.A., Garau V., Bandettini M., Caputi S., Lörincz A., et al. Prescriptions of NSAIDs to patients undergoing third molar surgery : an observational, prospective, multicentre survey. Clin Drug Investig. 2008; 28 (10): 657-68. DOI:  

31.   Jianda X., Yuxing Q., Yi G., Hong Z., Libo P., Jianning Z. Impact of preemptive analgesia on inflammatory responses and rehabilitation after primary total knee arthroplasty: a controlled clinical study. Sci Rep. 2016; 31 (6): 303–54. DOI:  

32.   Kan S.L., Yang B., Ning G,Z., Chen L.X., Li Y.L., Gao S.J.,  et al. Nonsteroidal anti-inflammatory drugs as prophylaxis for heterotopic ossification after total hip arthroplasty. Medicine (Baltimore). 2015; 94 (18): e828. DOI:

Sergey L. Dzemeshkevich
MD, Professor (Moscow, Russia)
Medicine today

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