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3 . 2022

Early prevention before and after surgical complications in children with congenital cleft upper lip and palate


Early, from the first days of life, correction of intestinal microbiocenosis disorders in children with probiotics (bifido + lactobacilli) of intestinal microbiocenosis in children helps to normalize the composition of the intestinal microflora, indicators of cellular and humoral immunity, iron metabolism, physical development, reduce the incidence of concomitant diseases and postoperative complications and their early rehabilitation.

Keywords:cleft lip; cleft palate; congenital anomaly; microflora

Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Murtazaev S.M., Amanullaev R.A., Mirkhayidov M.M., Asrorova K.S. Early prevention before and after surgical complications in children with congenital cleft upper lip and palate. Clinical and Experimental Surgery. Petrovsky Journal. 2022; 10 (3): 89–99. DOI:  (in Russian)


1.     Azimov M. Optimization of wound healing in plastic congenital defects of the palate in children with bacterial lysates: Diss. Tashkent, 2007: 128 p. (in Russian)

2.     Yuldashev A.Yu., Nishanova A.A., Yuldashev A.A. Regulation of homeostasis in the small intestine and the mechanisms of development of multiple organ failure in its violation. Meditsinskiy zhurnal Uzbekistana [Medical Journal of Uzbekistan]. 2009; (1): 66–9. (in Russian)

3.     Murtazaev S.M. Early complex preoperative preparation and treatment of children with congenital through cleft lip and palate at the stages of rehabilitation: Diss. Tashkent, 2010. (in Russian)

4.     Makhkamov E.U. Early treatment of children with congenital cleft lip and palate: Diss. Moscow, 1981: 221 p. (in Russian)

5.     Minisaev D.A., Sarkisova S.M., Plotnikov T.N. Concomitant diseases in children with congenital cleft lip and palate. Meditsinskiy zhurnal Uzbekistana [Medical Journal of Uzbekistan]. 1980; (9): 74–6. (in Russian)

6.     Murtazaev S.M., Yuldashev A.Yu., et al. The effect of eubiotics on the state of intestinal microflora and parameters of the immune system in children with congenital cleft lip and palate. Pediatriya. Zhurnal imeni G.N. Speranskogo [Pediatrics Journal named after G.N. Speransky]. 2003; 82 (2): 118–9. (in Russian)

7.     Nagirny Ya.P. Values of resistance factors of the body in predicting postoperative complications in the surgical treatment of children with congenital cleft lip and palate: Diss. Moscow, 1990: 163 p. (in Russian)

8.     Goodacre R. Metabolomics of a super organism. J Nutr. 2007; 137 (suppl 1): S259–66.

9.     Murtazaev S.M. Influence of congenital cleft lip and palate on intestinal microbiocenosis and child development. Sredneaziatskiy nauchno-prakticheskiy zhurnal «Stomatologiya» [Central Asian Scientific and Practical Journal «Stomatologiya»]. 2009; (1–2): 81–4. (in Russian)

10. Gracheva N.M., Yushchuk N.D., Chuprinina R.P. Intestinal dysbacteriosis causes, diagnosis, use of bacterial biological preparations: Manual for doctors and students. Moscow, 1996: 45 p. (in Russian)

11. Buglanov A.A., Averyanova A.A. Express method for determining the concentration of transferron in human serum. Laboratornoe delo [Laboratory Work]. 1985; (9): 691–3. (in Russian)

12. Buglanov A.A., Kazakbaeva Kh.M., Salikhov T.A. Enzyme-linked immunosorbent assay for determining the concentration of ferritin in human blood serum. Gematologiya i transfuziologiya [Hematology and Transfusiology]. 1988; (5): 53–4. (in Russian)

13. Usmanov A.T. Stage-by-stage surgical treatment of congenital through clefts of the upper lip and palate: Diss. Tashkent, 2001: 126 p. (in Russian)

14. Shenderov B.A. Normal microflora and its role in maintaining human health. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology]. 1992; (1): 61–5. (in Russian)

15. Lyte M. The microbial organ in the gut as a driver of homeostasis and disease. Med Hypotheses. 2010; 74 (4): 634–8. DOI: 2009.10.025  

16. Beida-Ferre P., Alcarar L.D., Gabrera-Rubio R., et al. The oral metagenome in health and disease. SME J. 2011; 6 (1): 46–56. DOI:  

17. Turnbaugh P.J., Ley R.E., Hamady M. The human microbiome project. Nature. 2007; 449 (7164): 804–10. DOI:  

18. Clarke G., Stilling R.M., Kennedy P.J., et al Minireview. Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014; 28 (8): 1221–38. DOI:  

19. Payne M.S., Bayatibojakhi S. Exploring preterm birth as a polymicrobial disease: an overview of the uterine microbiome. Front Immunol. 2014; 5: 595. DOI:  

20. Anurova A.E., Elizarova V.M., Shchegoleva V.D. Clinical parallels of the dental health of a child with congenital cleft lip and palate and his mother. In: Congenital and hereditary pathology of the head, face and neck in children: actual issues of complex treatment: Proceedings of the 3rd All-Russian Scientific Conference. Moscow, 2009: 22–4. (in Russian)

21. Bel’mer S.V., Khavkina A.N. Practical guide to childhood diseases. Moscow, 2003: 198–201. (in Russian)

22. Kau A.L., Ahern P.P., Griffin N.N., et al. Human nutrition the gut microbiome and the immune system. Nature. 2011; 474 (7351): 327–36. DOI:  

23. Murtazaev S.M., Yuldashev A.Yu. Method of prevention of pre and postoperative complications in children with congenital cleft lip and palate. Patent of the Republic of Uzbekistan. H.P.C. MKI 6A61 K35/74 dated 15.01.1997. (in Russian)

24. Luft V.M. Theoretical and applied trophology of colonoproctology. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology]. 2003; 14 (4): 13–6. (in Russian)

25. Karimova G.E. Substantiation of the method of prevention and treatment of iron deficiency anemia in pregnant women with the help of eubiotics: Diss. Tashkent 1999. (in Russian)

26. Garib F.Yu., Zalyalieva M.V. Regulatory materials on the content of individual subpopulations of lymphocytes in human peripheral blood in the age aspect. Methodological recommendation. Tashkent, 1992: 9 p. (in Russian)

27. Bondarenko V.M., Gracheva N.I., Matsulevich T.V. Intestinal dysbacteriosis in adults. Moscow: Meditsina, 2003: 206 p. (in Russian)

28. Korot’ko G.F. Physiology of the digestive system. Krasnodar, 2009. (in Russian)

29. Makarova S.G., Broeva M.I. The influence of various factors on the early stages of the formation of the intestinal microbiota. Pediatricheskaya farmakologiya [Pediatric Pharmacology]. 2016; 13 (3): 270–82. DOI:  (in Russian)

Sergey L. Dzemeshkevich
MD, Professor (Moscow, Russia)
Medicine today

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