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1 . 2023

The role of bronchial circulation in preventing chronic pulmonary dysfunction

Abstract

Chronic lung allograft dysfunction remains one of the main causes limiting long-term survival in lung transplant recipients. The possible way to solve this problem may be a complete anatomical connection of all structures of the transplanted lung, including the bronchial arteries. This review focuses on the role of maintaining bronchial blood flow and microvasculature in preventing the development of trophic failure and chronic graft dysfunction in patients undergoing lung transplantation

Keywords:lung transplantation; respiratory failure; revascularization of bronchial arteries; chronic lung allograft dysfunction

Funding. The work was financially supported by the Russian Science Foundation, project 23-25-10013 (Agreement No. r-52 with the Ministry of Science and Innovation Policy of the Novosibirsk Region).
Conflict of interest. The authors declare no conflict of interest.
For citation: Zhulkov M.O., Sirota D.A., Rukаvishnikov D.A., Agaeva Kh.A., Sabetov A.K., Makaev Alexander G., Protopopov A.V., Makaev Andrey G., Fomichev A.V., Khvan D.S., Limanskiy A.D., Chernyavskiy A.M. The role of bronchial circulation in preventing chronic pulmonary dysfunction. Clinical and Experimental Surgery. Petrovsky Journal. 2023; 11 (1): 27–31. DOI: https://doi.org/10.33029/2308-1198-2023-11-1-27-31  (in Russian)

References

1.     Deffebach M.E., Charan N.B., Lakshminarayan S., Butler J. The bronchial circulation. Small, but a vital attribute of the lung. Am Rev Respir Dis. 1987; 135 (2): 463–81.

2.     Dhillon G.S., Zamora M.R., Roos J.E., Sheahan D., Sista R.R., Van der Starre P., et al. Lung transplant airway hypoxia: a diathesis to fibrosis? Am. J. Respir. Crit. Care Med. 2010; 182 (2): 230–6.

3.     Luckraz H., Goddard M., McNeil K., Atkinson C., Sharples L.D., Wallwork J. Is obliterative bronchiolitis in lung transplantation associated with microvascular damage to small airways? Ann Thorac Surg. 2006; 82 (4): 1212–8.

4.     Chambers D.C., Cherikh W.S., Goldfarb S.B., Hayes D., Kucheryavaya A.Y., Toll A.E., et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth adult lung and heart-lung transplant report-2018; Focus theme: Multiorgan Transplantation. J Heart Lung Transplant. 2018; 37 (10): 1169–83.

5.     Verleden G.M., Glanville A.R., Lease E.D., Fisher A.J., Calabrese F., Corris P.A., et al. Chronic lung allograft dysfunction: definition, diagnostic criteria, and approaches to treatment – A consensus report from the Pulmonary Council of the ISHLT. J Heart Lung Transplant. 2019; 38 (5): 493–503. DOI: https://doi.org/10.1016/j.healun.2019.03.009  

6.     Nykänen A., Raivio P., Peräkylä L., Stark C., Huuskonen A., Lemström K., et al. Incidence and impact of chronic lung allograft dysfunction after lung transplantation – single-center 14-year experience. Scand Cardiovasc J. 2020; 54 (3): 192–9. DOI: https://doi.org/10.1080/14017431.2020.1726444

7.     Jiang X., Sung Y.K., Tian W., Qian J., Semenza G.L., Nicolls M.R. Graft microvascular disease in solid organ transplantation. J Mol Med. 2014; 92 (8): 797–810. DOI: https://doi.org/10.1007/s00109-014-1173-y  

8.     Nicolls M.R., Hsu J.L., Jiang X. Microvascular injury after lung transplantation. Curr Opin Organ Transplant. 2016; 21 (3): 279–84. DOI: https://doi.org/10.1097/mot.0000000000000307

9.     Glanville A.R., Verleden G.M., Todd J.L., Benden C., Calabrese F., Gottlieb J., et al. Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome ― A consensus report from the Pulmonary Council of the ISHLT. J Heart Lung Transplant. 2019; 38 (5): 483–92. DOI: https://doi.org/10.1016/j.healun.2019.03.008  

10. Paredi P., Barnes P.J. The airway vasculature: Recent advances and clinical implications // Thorax. 2009; 64 (5): 444–50. DOI: https://doi.org/10.1136/thx.2008.100032  

11. Pump K.K. Distribution of bronchial arteries in the human lung. Chest. 1972; 62 (4): 447–51. DOI: https://doi.org/10.1378/chest.62.4.447  

12. Walker C.M., Rosado-de-Christenson M.L., Martínez-Jiménez S., Kunin J.R., Wible B.C. Bronchial arteries: anatomy, function, hypertrophy, and anomalies. Radiographics. 2015; 35 (1): 32–49. DOI: https://doi.org/10.1148/rg.351140089  

13. Nicolls M.R., Zamora M.R. Bronchial blood supply after lung transplantation without bronchial artery revascularization. Curr Opin Organ Transplant. 2010; 15 (5); 563–7. DOI: https://doi.org/10.1097/mot.0b013e32833deca9  

14. Schreinemakers H.H., Weder W., Miyoshi S., Harper B.D., Shimokawa S., Egan T.M., et al. Direct revascularization of bronchial arteries for lung transplantation: An anatomical study. Ann Thorac Surg. 1990; 49 (1): 44–54. DOI: https://doi.org/10.1016/0003-4975(90)90355-a  

15. Daly R.C., McGregor C.G.A. Routine immediate direct bronchial artery revascularization for single-lung transplantation. Ann Thorac Surg. 1994; 57 (6): 1446–52. DOI: https://doi.org/10.1016/0003-4975(94)90099-x  

16. Couraud L., Baudet E., Martigne C., Roques X., Velly J.F., Laborde N., et al. Bronchial revascularization in double-lung transplantation: A series of 8 patients. Ann Thorac Surg. 1992; 53 (1): 88–94. DOI: https://doi.org/10.1016/0003-4975(92)90764-u  

17. Pettersson G.B., Yun J.J., Norgaard M.A. Bronchial artery revascularization in lung transplantation: Techniques, experience, and outcomes. Opin Organ Transplant. 2010; 15 (5): 572–7. DOI: https://doi.org/10.1097/mot.0b013e32833e16fc  

18. Arterial anastomoses, bronchopulmonary arteries, and pulmobronchial arteries in perinatal lungs [Electronic resource]. URL: https://pubmed.ncbi.nlm.nih.gov/6022190/  (date of access March 06, 2021).

19. The bronchial arteries and their connections with other vessels in the human lung [Electronic resource]. URL: https://pubmed.ncbi.nlm.nih.gov/13005350/  (date of access March 06, 2021).

20. Liebow A.A. Patterns of origin and distribution of the major bronchial arteries in man. Am J Anat. 1965; 117 (1): 19–32. DOI: https://doi.org/10.1002/aja.1001170103  

21. Metras H. Note preliminaire sur la greffe totale du poumon chez le chien. C R Acad Sci (Paris). 1950; 231: 1176–7.

22. The significance of bronchial circulation in lung transplantation [Electronic resource]. URL: URL: https://pubmed.ncbi.nlm.nih.gov/4922675/  (date of access March 06, 2021).

23. Sundset A., Tadjkarimi S., Khaghani A., Yacoub M. H. Human en bloc double-lung transplantation: Bronchial artery revascularization improves airway perfusion. Ann Thorac Surg. 1997; 63 (3): 790–5. DOI: https://doi.org/10.1016/s0003-4975(96)01273-8  

24. Kamler M., Nowak K., Bock M., Herold U., Motsch J., Hagl S., et al. Bronchial artery revascularization restores peribronchial tissue oxygenation after lung transplantation. J Heart Lung Transplant. 2004; 23 (6): 763–6. DOI: https://doi.org/10.1016/j.healun.2003.07.016  

25. Norgaard M.A., Andersen C.B., Pettersson G. Airway epithelium of transplanted lungs with and without direct bronchial artery revascularization. Eur J Cardiothorac Surg. 1999; 15 (1): 37–44. DOI: https://doi.org/10.1016/s1010-7940(98)00292-9  

26. Nowak K.A.I., Kamler M., Bock M., Motsch J., Hagl S., Jakob H., et al. Bronchial artery revascularization affects graft recovery after lung transplantation. Am J Respir Crit Care Med. 2002; 165 (2): 216–20. DOI: https://doi.org/10.1164/ajrccm.165.2.2012101   

27. Norgaard M.A., Andersen C.B., Pettersson G. Does bronchial artery revascularization influence results concerning bronchiolitis obliterans syndrome and/or obliterative bronchiolitis after lung transplantation? Eur J Cardiothorac Surg. 1998; 14 (3): 311–8. DOI: https://doi.org/10.1016/s1010-7940(98)00182-1  

28. Haglin J.J., Ruiz E., Baker R.C., Anderson W.R. Histologic studies of human lung allotransplantation. In: Morphology in Lung Transplantation. Basel, Switzerland: S. Karger, 1973: 13–22. DOI: https://doi.org/10.1159/000393947  

29. Patterson G.A. Airway revascularization: Is it necessary? Ann Thorac Surg. 1993; 56 (4): 807–8. DOI: https://doi.org/10.1016/0003-4975(93)90335-f  

30. Daly R.C., Tadjkarimi S., Khaghani A., Banner N.R., Yacoub M.H. Successful double-lung transplantation with direct bronchial artery revascularization. Ann Thorac Surg. 1993; 56 (4): 885–92. DOI: https://doi.org/10.1016/0003-4975(93)90350-q  

31. Pettersson G., Arendrup H., Mortensen S.A., Aldershvile J., Thiis J.J., Aggestrup S., et al. Early experience of double-lung transplantation with bronchial artery revascularization using mammary artery. Eur J Cardiothorac Surg. 1994; 8 (10): 520–4. DOI: https://doi.org/10.1016/1010-7940(94)90069-8  

32. Baudet E.M., Dromer C., Dubrez J., Jougon J.B., Roques X., Velly J.F. Intermediate-term results after en bloc double-lung transplantation with bronchial arterial revascularization. Bordeaux Lung and Heart-Lung Transplant Group. J Thorac Cardiovasc Surg. 1996; 112 (5): 1292–300. DOI: https://doi.org/10.1016/s0022-5223(96)70143-5  

33. Luckraz H., Goddard M., McNeil K., Atkinson C., Charman S.C., Stewart S., et al. Microvascular changes in small airways predispose to obliterative bronchiolitis after lung transplantation. J Heart Lung Transplant. 2004; 23 (5): 527–31. DOI: https://doi.org/10.1016/j.healun.2003.07.003  

34. Pettersson G.B., Karam K., Thuita L., Johnston D.R., McCurry K.R., Kapadia S.R., et al. Comparative study of bronchial artery revascularization in lung transplantation. J Thorac Cardiovasc Surg. 2013; 146 (4): 894–900. DOI: https://doi.org/10.1016/j.jtcvs.2013.04.030  

35. Tong, M.Z., Johnston D.R., Pettersson G.B. Bronchial artery revascularization in lung transplantation: revival of an abandoned operation. Curr Opin Organ Transplant. 2014; 19 (5): 460–7. DOI: https://doi.org/10.1097/mot.0000000000000114  

36. Aoki M., Schafers H.J., Inui K., Klipsch N., Demertzis S., Kotzerke J., et al. Bronchial circulation after experimental lung transplantation: the effect of direct revascularization of a bronchial artery. Eur J Cardiothorac Surg. 1991; 5 (11): 561–5. DOI: https://doi.org/10.1016/1010-7940(91)90219-a  

37. Guzman-Pruneda F.A., Orr Y., Trost J.G., Zhang W., Das S., Melicoff E., et al. Bronchial artery revascularization and en bloc lung transplant in children. J Heart Lung Transplant. 2016; 35 (1): 122–9. DOI: https://doi.org/10.1016/j.healun.2015.08.010

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CHIEF EDITOR
CHIEF EDITOR
Sergey L. Dzemeshkevich
MD, Professor (Moscow, Russia)

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